Primary Identifier | MGI:1921984 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 74734 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including GTP binding activity; GTPase activity; and kinase inhibitor activity. Involved in T cell differentiation and mast cell activation. Located in cytoplasm and immunological synapse. Is expressed in cranial ganglion; dorsal root ganglion; and sensory organ. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human RHOH (ras homolog family member H). PHENOTYPE: Mice homozygous for disruptions in this gene display abnormalities in the differentiation of T cells and mast cell physiology. [provided by MGI curators] |