| Primary Identifier | MGI:102960 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 22165 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in T cell receptor signaling pathway; adaptive immune response; and positive regulation of cytokine production. Acts upstream of or within NK T cell differentiation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including hemolymphoid system; lung; male reproductive gland or organ; stomach mesentery; and vertebral axis musculature. Orthologous to human TXK (TXK tyrosine kinase). PHENOTYPE: Homozygous mutation of this gene results in increased susceptibility to parasitic (Toxoplasma gondii) infection and decreased cytokine secretion in stimulated splenocytes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
