| Primary Identifier | MGI:99698 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 12753 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and histone acetyltransferase activity. Involved in several processes, including circadian regulation of gene expression; negative regulation of glucocorticoid receptor signaling pathway; and regulation of DNA-templated transcription. Acts upstream of or within circadian rhythm. Located in chromatoid body and nucleus. Part of CLOCK-BMAL transcription complex. Is expressed in several structures, including alimentary system; ear; early conceptus; genitourinary system; and nervous system. Used to study bipolar disorder; diabetes mellitus; and sleep disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease and alcohol use disorder. Orthologous to human CLOCK (clock circadian regulator). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal circadian phase. Mice homozygous for a spontaneous mutation exhibit abnormal circadian rhythm, reproduction, behavior, hair cycle, macronutrient absorption, and metabolism. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
