| Primary Identifier | MGI:1313259 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20555 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable RNA nuclease activity and ribosome binding activity. Acts upstream of or within several processes, including negative regulation of G1/S transition of mitotic cell cycle; negative regulation of T cell proliferation; and negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; oviduct; and spleen. Orthologous to human SLFN12 (schlafen family member 12). PHENOTYPE: Mice homozygous for a null allele show normal thymus cellularity and expression of cell surface markers on thymocytes and peripheral lymphocytes. Mice homozygous for a different null allele show normal immune cell populations and MOG-induced experimental autoimmune encephalitis development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
