Primary Identifier | MGI:2388280 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 231329 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including alimentary system; brain; integumental system; respiratory system; and sensory organ. Orthologous to human POLR2B (RNA polymerase II subunit B). PHENOTYPE: Mice homozygous for a knock-out allele show abnormal morula morphology and complete embryonic lethality before implantation. In vitro, embryos fail to hatch from the zona pellucida and die after 3 days in culture. [provided by MGI curators] |