| Primary Identifier | MGI:1096868 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 20311 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable CXCR chemokine receptor binding activity; chemokine activity; and identical protein binding activity. Acts upstream of or within several processes, including leukocyte homeostasis; regulation of neutrophil mediated killing of gram-negative bacterium; and response to lipopolysaccharide. Predicted to be active in extracellular space. Is expressed in central nervous system; liver lobe; molar; and sensory organ. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to several human genes including CXCL6 (C-X-C motif chemokine ligand 6). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased chemokine scavenging, decrease suscetibility to bacterial infection, and altered neutrophil physiology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
