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Protein Coding Gene : Ppbp pro-platelet basic protein

Primary Identifier  MGI:1888712 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  57349
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables chemokine activity. Acts upstream of or within leukocyte migration involved in inflammatory response. Predicted to be located in platelet alpha granule. Predicted to be active in extracellular space. Is expressed in genitourinary system; gut; hemolymphoid system; and liver lobe. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to human PPBP (pro-platelet basic protein).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired leukocyte shape change and migration following vascular injury. [provided by MGI curators]
  • synonyms:
  • Ppbp,
  • 2400003M24Rik,
  • TGB,
  • beta-TG,
  • NAP-2-L1,
  • b-TG1,
  • AI854500,
  • RIKEN cDNA 2400003M24 gene,
  • MDGF,
  • THBGB1,
  • NAP-2,
  • MGI:2141003,
  • CTAPIII,
  • Scyb7,
  • chemokine (C-X-C motif) ligand 7,
  • Cxcl7,
  • TGB1,
  • LA-PF4,
  • MGI:1922842,
  • expressed sequence AI854500,
  • LDGF,
  • pro-platelet basic protein,
  • CTAP3

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

4 Involved In Mutations

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0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

15 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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