Primary Identifier | MGI:1888712 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 57349 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chemokine activity. Acts upstream of or within leukocyte migration involved in inflammatory response. Predicted to be located in platelet alpha granule. Predicted to be active in extracellular space. Is expressed in genitourinary system; gut; hemolymphoid system; and liver lobe. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to human PPBP (pro-platelet basic protein). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired leukocyte shape change and migration following vascular injury. [provided by MGI curators] |