Primary Identifier | MGI:108068 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 14825 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable chemokine activity. Involved in several processes, including positive regulation of hematopoietic stem cell proliferation; positive regulation of neutrophil mediated killing of fungus; and positive regulation of superoxide anion generation. Located in extracellular space. Is expressed in several structures, including cardiovascular system; liver; nervous system; retina; and small intestine. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1) and CXCL2 (C-X-C motif chemokine ligand 2). PHENOTYPE: Targeted mutations in this gene when combine with targeted mutation of Ldlr decreases susceptibility to atherosclerotic lesions. [provided by MGI curators] |