Primary Identifier | MGI:1919170 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 71920 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables growth factor activity and transmembrane receptor protein tyrosine kinase activator activity. Involved in epidermal growth factor receptor signaling pathway and positive regulation of epithelial cell proliferation. Acts upstream of or within MAPK cascade. Is active in extracellular space. Is expressed in several structures, including alimentary system; arterial system; dorsal root ganglion; hair follicle; and male reproductive gland or organ. Orthologous to human EPGN (epithelial mitogen). PHENOTYPE: Mice homozygous for a knock-out allele exhibit moderate increase in absolute pancreas and spleen weight but normal epidermis and pilosebaceous unit development. [provided by MGI curators] |