Primary Identifier | MGI:2442040 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 23881 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable mRNA binding activity and molecular condensate scaffold activity. Predicted to be involved in positive regulation of stress granule assembly; protein homooligomerization; and stress granule assembly. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in cytoplasmic stress granule and cytosol. Is expressed in several structures, including central nervous system; ovary; sensory organ; and tooth. Orthologous to human G3BP2 (G3BP stress granule assembly factor 2). PHENOTYPE: Despite increased male germ cell apoptosis, male mice homozygous for a conditional allele activated in Sertoli cells or germ cells exhibit normal spermatogenesis and fertility. [provided by MGI curators] |