| Primary Identifier | MGI:2445289 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 231507 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; positive regulation of transcription by RNA polymerase II; and response to cold. Predicted to be located in nucleoplasm. Is expressed in several structures, including extraembryonic component; gut; hemolymphoid system; liver lobe; and prostate gland lobe. Orthologous to human PLAC8 (placenta associated 8). PHENOTYPE: Mice homozygous for a null allele exhibit decreased neutrophil capacity for intracellular bacteria killing and impaired brown adipose tissue and thermoregulation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
