Primary Identifier | MGI:3603816 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 231510 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables glycerol-3-phosphate O-acyltransferase activity. Involved in glycerol-3-phosphate metabolic process; phospholipid biosynthetic process; and triglyceride biosynthetic process. Located in endoplasmic reticulum. Orthologous to human GPAT3 (glycerol-3-phosphate acyltransferase 3). PHENOTYPE: Under high-fat feeding, mice homozygous for a knock-out allele exhibit increased energy expenditure, improved glucose homeostasis, enlarged livers, increased total serum cholesterol levels, altered liver cholesterol metabolism, and female-specific protection from diet-induced obesity. [provided by MGI curators] |