| Primary Identifier | MGI:96389 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 15891 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable integrin binding activity and small molecule binding activity. Acts upstream of or within bone mineralization; cellular response to growth factor stimulus; and extracellular matrix organization. Predicted to be located in extracellular space and vesicle. Is expressed in several structures, including facial prominence; jaw; limb; perichondrium; and skeleton. Orthologous to human IBSP (integrin binding sialoprotein). PHENOTYPE: Mice homozygous for a knock-out allele show reduced body weight/size, delayed long bone growth and mineralization with low bone turn over due to reduced osteoclast formation, delayed intramembranous ossification, progressive periodontal breakdown, and severe alveolar and mandibular bone loss. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
