Primary Identifier | MGI:2137384 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 94111 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable extracellular matrix protein binding activity. Acts upstream of or within negative regulation of bone mineralization. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including aorta; bone; connective tissue; lower jaw mesenchyme; and lower leg mesenchyme. Orthologous to human MEPE (matrix extracellular phosphoglycoprotein). PHENOTYPE: Mice homozygous for disruptions in this gene have increased amounts of trabecular bone in their skeleton and undergo less age related bone loss. Otherwise, they display a normal phenotype. [provided by MGI curators] |