| Primary Identifier | MGI:2140839 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 100604 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Contributes to volume-sensitive anion channel activity. Involved in monoatomic anion transmembrane transport and protein hexamerization. Acts upstream of or within fat cell differentiation. Located in endoplasmic reticulum. Part of monoatomic ion channel complex. Is expressed in retina. Orthologous to human LRRC8C (leucine rich repeat containing 8 VRAC subunit C). PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction in body weight, white adipose tissue weight, and insulin resistance on a high-fat diet, indicating protection from diet-induced obesity and insulin resistance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
