Primary Identifier | MGI:2385894 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 231583 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chloride transmembrane transporter activity; oxalate transmembrane transporter activity; and sulfate:bicarbonate antiporter activity. Involved in chloride transport; oxalate transport; and sulfate transmembrane transport. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; integumental system; liver; nose; and urinary system. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human SLC26A1 (solute carrier family 26 member 1). PHENOTYPE: Mice homozygous for disruptions in this gene develop kidney stones and have an increased susceptibility to acetaminophen-induced liver damage. [provided by MGI curators] |