| Primary Identifier | MGI:1270126 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 22241 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables Hsp90 protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including macroautophagy; regulation of macromolecule biosynthetic process; and response to mitochondrial depolarisation. Acts upstream of or within several processes, including Ras protein signal transduction; generation of neurons; and radial glia guided migration of cerebellar granule cell. Located in several cellular components, including cytoplasmic vesicle membrane; neuronal cell body; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; retina; and tibialis anterior. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1). PHENOTYPE: Null homozygotes have blood defects including an increase in mean corpuscular volume and the presence of red blood cells that contain mitochondria. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
