| Primary Identifier | MGI:1309516 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 22022 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation. Acts upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization and prevention of polyspermy. Is active in Golgi lumen and trans-Golgi network. Orthologous to human TPST2 (tyrosylprotein sulfotransferase 2). PHENOTYPE: Spontaneous mutants show a delayed rise and a prolonged deficit of pituitary growth hormone resulting in delayed pubertal growth, hypothyroidism, and an enlarged adenohypophysis with aberrant chromophobic cells. Homozygous null mice show a modest but transient pubertal growth lag and male sterility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
