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Protein Coding Gene : Tpst2 protein-tyrosine sulfotransferase 2
Primary Identifier  MGI:1309516 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  22022
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation. Acts upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization and prevention of polyspermy. Is active in Golgi lumen and trans-Golgi network. Orthologous to human TPST2 (tyrosylprotein sulfotransferase 2).
PHENOTYPE: Spontaneous mutants show a delayed rise and a prolonged deficit of pituitary growth hormone resulting in delayed pubertal growth, hypothyroidism, and an enlarged adenohypophysis with aberrant chromophobic cells. Homozygous null mice show a modest but transient pubertal growth lag and male sterility. [provided by MGI curators]
  • synonyms:
  • protein-tyrosine sulfotransferase 2,
  • AI448750,
  • Tpst2,
  • expressed sequence AI448750,
  • Tango13b,
  • D5Ucla3,
  • grm,
  • MGD-MRK-16734,
  • MGI:99932,
  • DNA segment, Chr 5, University of California at Los Angeles 3,
  • grt,
  • MGD-MRK-7379,
  • MGI:2140887,
  • MGI:93474,
  • growth retarded
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2 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

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Function

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Interactions

7 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

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