Primary Identifier | MGI:1858230 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 53890 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable histone binding activity; snRNA binding activity; and ubiquitin-specific protease binding activity. Acts upstream of or within cell morphogenesis; hematopoietic stem cell proliferation; and homeostasis of number of cells. Located in Cajal body. Is expressed in several structures, including blastocyst; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture. [provided by MGI curators] |