Primary Identifier | MGI:1925082 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 77832 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Located in desmosome and keratin filament. Part of ciliary transition fiber. Is expressed in inner ear and olfactory epithelium. Orthologous to human TCHP (trichoplein keratin filament binding). PHENOTYPE: Mice homozygous for a null allele are resistant to high-fat diet-induced obesity and show abnormal adipogenesis with adipogenic progenitor cells showing elongated cilia and impaired adipocyte differentiation. [provided by MGI curators] |