| Primary Identifier | MGI:3610315 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 333050 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables MAP-kinase scaffold activity and mitogen-activated protein kinase kinase binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within calcium-mediated signaling and positive regulation of MAPK cascade. Located in cytosol and plasma membrane. Orthologous to human KSR2 (kinase suppressor of ras 2). PHENOTYPE: Homozygous mice exhibit increased body fat and obesity, resulting from hyperphagia. Mice are also glucose intolerant and have high serum cholesterol, ALT, serum lipids and show hepatic steatosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
