Primary Identifier | MGI:1333110 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 17165 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mitogen-activated protein kinase binding activity; p53 binding activity; and protein serine/threonine kinase activity. Involved in Ras protein signal transduction; negative regulation of TOR signaling; and stress-induced premature senescence. Acts upstream of or within positive regulation of dendritic spine development. Located in cytoplasm; nucleus; and septin cytoskeleton. Part of protein-containing complex. Is expressed in several structures, including brain; lung; metanephros; and nasal epithelium. Orthologous to human MAPKAPK5 (MAPK activated protein kinase 5). PHENOTYPE: Homozygous mutant mice are viable, fertile, and show no overt abnormalities. [provided by MGI curators] |