| Primary Identifier | MGI:1354737 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 30841 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone H3K36 demethylase activity. Involved in several processes, including brain development; embryonic morphogenesis; and negative regulation of neuron apoptotic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II; positive regulation of cell growth; and positive regulation of stem cell population maintenance. Predicted to be located in nucleoplasm. Predicted to be part of PcG protein complex. Is expressed in several structures, including genitourinary system; lung; and telencephalon. Orthologous to human KDM2B (lysine demethylase 2B). PHENOTYPE: Mice homozygous for a targeted allele that does not express the long form protein exhibit exencephaly, fetal and postnatal lethality, coloboma, curly tail, oligozoospermia, increased apoptosis, and increased neuronal precursor proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
