Primary Identifier | MGI:106485 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 215707 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity. Predicted to be involved in innate immune response. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in centriole. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and sensory organ. Orthologous to human CCDC92 (coiled-coil domain containing 92). PHENOTYPE: Under high-fat diet conditions, mice homozygous for a knock-out allele show decreased obesity, increased insulin sensitivity and glucose tolerance, reduced adipocyte differentiation and macrophage infiltration and fibrosis in white adipose tissue, increased energy expenditure, and decreased hepatic steatosis. [provided by MGI curators] |