Primary Identifier | MGI:1928897 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 57749 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including RNA binding activity; mRNA cap binding complex binding activity; and protein kinase binding activity. Involved in regulatory ncRNA-mediated gene silencing and sperm DNA condensation. Located in chromatoid body; dense body; and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human PIWIL1 (piwi like RNA-mediated gene silencing 1). PHENOTYPE: Homozygotes for a targeted null mutation exhibit male sterility due to a block in spermatogenesis beginning at the round spermatid stage. [provided by MGI curators] |