| Primary Identifier | MGI:1195985 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 12418 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables several functions, including SUMO binding activity; SUMO ligase activity; and histone H3K27me3 reader activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of brown fat cell differentiation; and protein stabilization. Acts upstream of or within negative regulation of transcription by RNA polymerase II and protein sumoylation. Located in nuclear body. Is expressed in several structures, including adrenal gland; brain; gut; lung; and thymus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CBX4 (chromobox 4). PHENOTYPE: Homozygous inactivation of this gene results in complete neonatal lethality and severe thymus hypoplasia as a result of reduced thymocyte proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
