Primary Identifier | MGI:2684898 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 214292 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within labyrinthine layer development and myoblast fusion. Predicted to be located in plasma membrane. Is expressed in several structures, including extraembryonic component; ganglia; heart ventricle; musculoskeletal system; and placenta. Orthologous to human ERVFRD-1 (endogenous retrovirus group FRD member 1, envelope). PHENOTYPE: Mice homozygous for a knock-out allele exhibit lethality between E11.5 and E14.5 associated with defective placental layrinth formation, impaired placental transport, and increased trophoblast cells. [provided by MGI curators] |