| Primary Identifier | MGI:1926479 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 56743 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable SH2 domain binding activity. Predicted to be involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Predicted to be located in membrane raft. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human LAT2 (linker for activation of T cells family member 2). PHENOTYPE: Mice homozygous for a null allele have abnormal mast cell physiology and increased anti-nuclear antigen antibody level. Mice homozygous for another null allele show abnormal mast cell physiology, hyperactivated T cells, higher cytokine production, spleenhyperplasia and increased autoantibody level. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
