| Primary Identifier | MGI:104572 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 16885 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable heat shock protein binding activity and protein serine/threonine kinase activity. Acts upstream of or within positive regulation of axon extension and positive regulation of stress fiber assembly. Located in several cellular components, including focal adhesion; lamellipodium; and male germ cell nucleus. Is expressed in several structures, including alimentary system; early conceptus; embryo ectoderm; genitourinary system; and sensory organ. Used to study Williams-Beuren syndrome. Orthologous to human LIMK1 (LIM domain kinase 1). PHENOTYPE: Mice homozygous for disruptions in this gene display an abnormal actin cytoskeleton in neurons of the central nervous system and structural abnormalities of the dendritic spines. Long term potentiation is altered and behavioral anomalies are seen. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
