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Protein Coding Gene : Orai2 ORAI calcium release-activated calcium modulator 2
Primary Identifier  MGI:2443195 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  269717
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Located in membrane. Is expressed in several structures, including foregut; nervous system; nose; skin; and tooth. Orthologous to human ORAI2 (ORAI calcium release-activated calcium modulator 2).
PHENOTYPE: Homozygous KO mice show increased SOCE (store-operated Ca2+ entry) through CRAC (Ca2+ release-activated Ca2+) channels in T cells and higher CRAC currents. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA A730041O15 gene,
  • A730041O15Rik,
  • Orai2,
  • transmembrane protein 142B,
  • ORAI calcium release-activated calcium modulator 2,
  • Tmem142b
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