Primary Identifier | MGI:1913687 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 66437 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity; lipid binding activity; and molecular adaptor activity. Involved in mitochondrial fission. Located in mitochondrion. Is expressed in heart and tibialis anterior. Orthologous to human FIS1 (fission, mitochondrial 1). PHENOTYPE: Mice homozygous for a conditional allele activated in skeletal muscle exhibit impaired exercise endurance with abnormal mitochondria. Mice homozygous for another conditional allele activated in male germ cells exhibit abnormal mitochondrial morphology and arrested spermatid maturation. [provided by MGI curators] |