| Primary Identifier | MGI:1922853 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 69871 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Involved in notochord morphogenesis and positive regulation of cilium assembly. Predicted to be located in centrosome. Predicted to be active in centriole. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and hemolymphoid system. Orthologous to human PPP1R35 (protein phosphatase 1 regulatory subunit 35). PHENOTYPE: Mice homozygous for a knock-out allele lack primary cilia and show embryonic growth retardation, failure of embryo turning, distended pericardium, open neural tube, increased neural tube cell death, abnormal notochord development, and complete embryonic lethality during organogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
