Primary Identifier | MGI:106477 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 231803 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable 7SK snRNA binding activity and RNA 5'-gamma-phosphate methyltransferase activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in nucleus. Predicted to be part of 7SK snRNP. Is expressed in several structures, including adrenal gland; alimentary system; brain; early conceptus; and genitourinary system. Orthologous to human MEPCE (methylphosphate capping enzyme). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. [provided by MGI curators] |