Primary Identifier | MGI:2450529 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 231805 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable MHC class I protein binding activity. Predicted to act upstream of or within signal transduction. Predicted to be located in cell periphery and membrane. Is expressed in heart ventricle; lung; and urethra. Orthologous to several human genes including PILRA (paired immunoglobin like type 2 receptor alpha). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased increased alanine transferase, blood urea nitrogen, lactate dehydrogenase, neutrophils and mortality and altered liver morphology (massive hemorrhage, disorganized hepatic cords and karyolysis of hepatocytes) following treatment with LPS. [provided by MGI curators] |