Primary Identifier | MGI:2450532 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 170741 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables MHC class I protein binding activity. Involved in negative regulation of osteoclast differentiation. Acts upstream of or within myeloid dendritic cell activation. Located in plasma membrane. Orthologous to human PILRB (paired immunoglobin like type 2 receptor beta). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased susceptiblity to bacterial infection with S. aureus with decreased worm burden and mortality. [provided by MGI curators] |