Primary Identifier | MGI:1349439 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 26893 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable metallopeptidase activity. Predicted to be involved in protein deneddylation. Part of COP9 signalosome. Is expressed in several structures, including brown fat; central nervous system; male reproductive system; sensory organ; and urinary system. Orthologous to human COPS6 (COP9 signalosome subunit 6). PHENOTYPE: Mice homozygous for a gene trap allele or a transgenic gene disruption exhibit embryonic lethality. Mice heterozygous for a gene trap allele exhibit increased sensitivity to irradiation and decreased incidence of ionizing radiation-induced tumors. [provided by MGI curators] |