| Primary Identifier | MGI:1355311 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 50878 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable chromatin binding activity. Acts upstream of or within homologous chromosome pairing at meiosis and protein localization to chromosome. Located in lateral element; male germ cell nucleus; and transverse filament. Part of meiotic cohesin complex. Is expressed in bone marrow; brain; and genitourinary system. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 8 and spermatogenic failure 61. Orthologous to human STAG3 (STAG3 cohesin complex component). PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit azoospermia and lack oocytes. Homozygous knockout affects chromosomal synapsis, cross-over and double-strand breaks during male meiosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
