Primary Identifier | MGI:108013 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 22255 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable sequence-specific double-stranded DNA binding activity. Acts upstream of or within several processes, including cartilage condensation; central nervous system development; and common myeloid progenitor cell proliferation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human UNCX (UNC homeobox). PHENOTYPE: Homozygous null mutants exhibit severe skeletal defects, including absence of pedicles, transverse processes and proximal ribs. Mutants die around birth from respiratory failure. [provided by MGI curators] |