| Primary Identifier | MGI:1916978 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 108723 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable CARD domain binding activity. Involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell receptor signaling pathway; and positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including lymphocyte differentiation; positive regulation of interleukin-2 production; and regulation of lymphocyte activation. Located in immunological synapse. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma; immunodeficiency 11A; and immunodeficiency 11B. Orthologous to human CARD11 (caspase recruitment domain family member 11). PHENOTYPE: Mice homozygous for a targeted null mutation exhibit defects in antigen receptor signalling in both T and B lymphocytes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
