| Primary Identifier | MGI:1344349 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 108086 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein K48-linked ubiquitination; protein catabolic process; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in Gordon Holmes syndrome. Orthologous to human RNF216 (ring finger protein 216). PHENOTYPE: Nullizygous mutations of this gene result in male infertility associated with decreased testis size and weight, impaired spermatogenesis, decreased male germ cell number, and increased male germ cell apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
