| Primary Identifier | MGI:1353448 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 15467 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables heme binding activity; protein homodimerization activity; and protein kinase activity. Involved in negative regulation of cell population proliferation; negative regulation of hemoglobin biosynthetic process; and protein autophosphorylation. Acts upstream of or within several processes, including macrophage differentiation; multicellular organismal-level iron ion homeostasis; and regulation of protein metabolic process. Located in cytoplasm. Is expressed in alimentary system; central nervous system; liver; nervous system; and spinal cord. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1). PHENOTYPE: Mice homozygous for a null allele exhibit enlarged heart size and abnormal red blood cell development, morphology, and physiology with macrocytic anemia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
