Primary Identifier | MGI:1914148 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 66898 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable proline-rich region binding activity. Predicted to be involved in actin crosslink formation; actin filament bundle assembly; and positive regulation of actin filament polymerization. Predicted to be located in plasma membrane. Predicted to be active in cytosol and nucleoplasm. Predicted to colocalize with actin cytoskeleton. Is expressed in several structures, including brain; gut; lung; and nose. Orthologous to human BAIAP2L1 (BAR/IMD domain containing adaptor protein 2 like 1). PHENOTYPE: Mice homozygous for a knock-out allele are developmentally normal with no overt defects in placental development. Mice homozygous for a different knock-out allele show increased circulating glucose and insulin levels, glucose intolerance, increased hepatic glucose production and insulin resistance. [provided by MGI curators] |