Primary Identifier | MGI:2141165 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 381686 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Acts upstream of or within blastocyst development and regulation of gene expression. Located in female germ cell nucleus and spindle. Is expressed in early conceptus; gonad; and liver. Orthologous to human KPNA7 (karyopherin subunit alpha 7). PHENOTYPE: Mice homozygous or heterozygous for a null mutation display smaller litter sizes with preferential loss of females and accelerated cell cycles post fertilization resulting in loss of embryos. [provided by MGI curators] |