Primary Identifier | MGI:2387638 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 231912 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables microtubule severing ATPase activity. Acts upstream of or within microtubule severing and spermatogenesis. Located in microtubule cytoskeleton. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human KATNAL1 (katanin catalytic subunit A1 like 1). PHENOTYPE: Mice homozygous for an ENU induced mutation display male infertility with decreased testis weight and premature exfoliation of spermatids from the seminiferous epithelium. [provided by MGI curators] |