| Primary Identifier | MGI:107505 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 11690 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including arachidonate binding activity; glutathione peroxidase activity; and glutathione transferase activity. Predicted to contribute to arachidonate 5-lipoxygenase activity. Acts upstream of or within leukotriene biosynthetic process and leukotriene production involved in inflammatory response. Located in nucleus. Is expressed in cerebral cortex; hemolymphoid system; limb long bone; liver; and vertebra. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma; brain infarction (multiple); breast cancer; and cerebral palsy. Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein). PHENOTYPE: Targeted mutations of this gene result in a complete defect in leukotriene production, resistance to platelet-activating factor mediated anaphylaxis, and reduced acute and chronic inflammatory responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
