| Primary Identifier | MGI:2442401 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 243725 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including actin filament binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within actin filament organization and calcium-mediated signaling. Located in cortical actin cytoskeleton; dendritic spine; and filopodium. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; hemolymphoid system gland; and skeletal muscle. Orthologous to human PPP1R9A (protein phosphatase 1 regulatory subunit 9A). PHENOTYPE: Mice homozygous for a knock-out allele exhibit defects in dopamine-mediated neuromodulation, deficient long-term potentiation at corticostriatal synapses, increased spontaneous excitatory post-synaptic current frequency, and enhanced locomotor activationin response to cocaine treatment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
