| Primary Identifier | MGI:2182066 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 252875 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable metal ion binding activity. Involved in central nervous system myelin formation; oligodendrocyte progenitor proliferation; and positive regulation of TORC1 signaling. Predicted to be located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Predicted to be part of GATOR2 complex. Predicted to be active in cytoplasm. Is expressed in retina. Orthologous to human MIOS (meiosis regulator for oocyte development). PHENOTYPE: Mice homozygous for a conditional allele activated in oligodendrocytes exhibit hypomyelination, decreased oligodendrocyte numbers, and reduced proliferation of oligodendrocyte precursors due to delayed cell cycle exit. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
