| Primary Identifier | MGI:1923539 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 75725 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable histone binding activity; histone reader activity; and zinc ion binding activity. Involved in germinal center B cell differentiation. Acts upstream of or within several processes, including lung alveolus development; negative regulation of mesenchymal cell proliferation involved in lung development; and negative regulation of platelet-derived growth factor receptor-alpha signaling pathway. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; hindlimb phalanx; nervous system; and tooth. Orthologous to human PHF14 (PHD finger protein 14). PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete neonatal lethality due to respiratory failure, pulmonary wall hypertrophy, abnormal sternum ossification, and increased proliferation of bone marrow-derived mesenchymal cells and mouse embryonic fibroblasts. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
