Primary Identifier | MGI:3041159 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 214704 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in flagellated sperm motility and mating. Acts upstream of or within cilium assembly and smoothened signaling pathway. Located in acrosomal vesicle and sperm flagellum. Part of radial spoke. Is expressed in several structures, including central nervous system; gut; male reproductive gland or organ; respiratory system; and thymus. Orthologous to human IQUB (IQ motif and ubiquitin domain containing). PHENOTYPE: Mice homozygous for a null allele exhibit male sterility associated with asthenozoospermia and reduced flagellum bending. [provided by MGI curators] |